PDB entry 5w5x

View 5w5x on RCSB PDB site
Description: Crystal structure of BAXP168G in complex with an activating antibody
Class: apoptosis/immune system
Keywords: Fab', BAX activation, unfolding, APOPTOSIS, APOPTOSIS-IMMUNE SYSTEM complex
Deposited on 2017-06-16, released 2018-06-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-06-27, with a file datestamp of 2018-06-22.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator BAX
    Species: Homo sapiens [TaxId:9606]
    Gene: BAX, BCL2L4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07812
      • engineered mutation (61)
      • engineered mutation (125)
      • engineered mutation (167)
    Domains in SCOPe 2.07: d5w5xa_
  • Chain 'H':
    Compound: 3C10 Fab' heavy chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 5W5X (0-End)
  • Chain 'L':
    Compound: 3C10 Fab' light chain
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 5W5X (0-End)
    Domains in SCOPe 2.07: d5w5xl1, d5w5xl2
  • Heterogens: EDO, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w5xA (A:)
mdgsgeqprgggptsseqimktgalllqgfiqdragrmggeapelaldpvpqdastkkls
eslkrigdeldsnmelqrmiaavdtdsprevffrvaadmfsdgnfnwgrvvalfyfaskl
vlkalstkvpelirtimgwtldflrerllgwiqdqggwdgllsyfgtgtwqtvtifvagv
ltasltiwkkmgss

    Sequence, based on observed residues (ATOM records): (download) 
    >5w5xA (A:)
gptsseqimktgalllqgfiqdragrmggeadastkklseslkrigdeldsnmelqrmia
avdtdsprevffrvaadmfsdgnfnwgrvvalfyfasklvlkalstkvpelirtimgwtl
dflrerllgwiqdqggwdgllsyfgtgtwqtvtifvagvltasltiw

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5w5xL (L:)
diqmtqspsflsasvgdrvtinckasqnvnkyldwyqqnlgeppklliyhtnslptgips
rfsgsgsgtdftltisslqvedvatyfclqhdsgltfgsgtkleikradaaptvsifpps
meqltsggatvvcfvnnfyprdisvkwkidgseqrdgvldsvtdqdskdstysmsstlsl
tkveyerhnlytcevvhktssspvvksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >5w5xL (L:)
diqmtqspsflsasvgdrvtinckasqnvnkyldwyqqnlgeppklliyhtnslptgips
rfsgsgsgtdftltisslqvedvatyfclqhdsgltfgsgtkleikradaaptvsifpps
meqltsggatvvcfvnnfyprdisvkwkidgseqrdgvldsvtdqdskdstysmsstlsl
tkveyerhnlytcevvhktssspvvksfnrne