PDB entry 5w1w

View 5w1w on RCSB PDB site
Description: Structure of the HLA-E-VMAPRTLVL/GF4 TCR complex
Class: immune system
Keywords: T-cell receptor, TCR, HLA-E, CMV, pMHC-TCR complex, Immune system
Deposited on 2017-06-05, released 2017-10-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w1wa1, d5w1wa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5w1wb1, d5w1wb2
  • Chain 'C':
    Compound: leader peptide of HLA class I histocompatibility antigen, A alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W (0-8)
  • Chain 'D':
    Compound: GF4 T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wd1, d5w1wd2
  • Chain 'E':
    Compound: GF4 T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1we1, d5w1we2
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w1wf1, d5w1wf2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5w1wg1, d5w1wg2
  • Chain 'H':
    Compound: leader peptide of HLA class I histocompatibility antigen, A alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W (0-8)
  • Chain 'I':
    Compound: GF4 T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wi1, d5w1wi2
  • Chain 'J':
    Compound: GF4 T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wj1, d5w1wj2
  • Chain 'K':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w1wk1, d5w1wk2
  • Chain 'L':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5w1wl1, d5w1wl2
  • Chain 'M':
    Compound: leader peptide of HLA class I histocompatibility antigen, A alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W (0-8)
  • Chain 'N':
    Compound: GF4 T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wn1, d5w1wn2
  • Chain 'O':
    Compound: GF4 T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wo1, d5w1wo2
  • Chain 'P':
    Compound: HLA class I histocompatibility antigen, alpha chain E
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-E, HLA-6.2, HLAE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5w1wp1, d5w1wp2
  • Chain 'Q':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5w1wq1, d5w1wq2
  • Chain 'R':
    Compound: leader peptide of HLA class I histocompatibility antigen, A alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W (0-8)
  • Chain 'S':
    Compound: GF4 T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1ws1, d5w1ws2
  • Chain 'T':
    Compound: GF4 T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 5W1W
    Domains in SCOPe 2.06: d5w1wt1, d5w1wt2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w1wA (A:)
gshslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseyw
dretrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydg
kdyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketll
hleppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepvtlrwkpas

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wA (A:)
shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
leppkthvthhpisdheatlrcwalgfypaeitltwqqghtqdtelvetrpagdgtfqkw
aavvvpsgeeqrytchvqheglpepvtlrwkp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5w1wB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5w1wD (D:)
gqqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngr
ltaqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdp
avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
ksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wD (D:)
qlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrlt
aqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffps

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5w1wE (E:)
dsgvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgni
lerfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledln
kvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplk
eqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
awgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wE (E:)
gvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgnile
rfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledlnkv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5w1wF (F:)
gshslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseyw
dretrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydg
kdyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketll
hleppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepvtlrwkpas

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wF (F:)
shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
leppkthvthhpisdheatlrcwalgfypaeitltwqqghtqdtelvetrpagdgtfqkw
aavvvpsgeeqrytchvqheglpepvtlrwkp

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5w1wG (G:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >5w1wI (I:)
gqqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngr
ltaqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdp
avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
ksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wI (I:)
qqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrl
taqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdpa
vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
sdfacanafnnsiipedtffps

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >5w1wJ (J:)
dsgvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgni
lerfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledln
kvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplk
eqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
awgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wJ (J:)
gvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgnile
rfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledlnkv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >5w1wK (K:)
gshslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseyw
dretrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydg
kdyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketll
hleppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepvtlrwkpas

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wK (K:)
shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
leppkthvthhpisdheatlrcwalgfypaeitltwqqghtqdtelvetrpagdgtfqkw
aavvvpsgeeqrytchvqheglpepvtlrwkp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5w1wL (L:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >5w1wN (N:)
gqqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngr
ltaqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdp
avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
ksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wN (N:)
qlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrlt
aqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrdfksnsavawsnksdf
acanafnnsiipedtffps

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >5w1wO (O:)
dsgvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgni
lerfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledln
kvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplk
eqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
awgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wO (O:)
gvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgnile
rfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledlnkv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >5w1wP (P:)
gshslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseyw
dretrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydg
kdyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketll
hleppkthvthhpisdheatlrcwalgfypaeitltwqqdgeghtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepvtlrwkpas

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wP (P:)
shslkyfhtsvsrpgrgeprfisvgyvddtqfvrfdndaasprmvprapwmeqegseywd
retrsardtaqifrvnlrtlrgyynqseagshtlqwmhgcelgpdrrflrgyeqfaydgk
dyltlnedlrswtavdtaaqiseqksndaseaehqrayledtcvewlhkylekgketllh
leppkthvthhpisdheatlrcwalgfypaeitltwqqghtqdtelvetrpagdgtfqkw
aavvvpsgeeqrytchvqheglpepvtlrwkp

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5w1wQ (Q:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >5w1wS (S:)
gqqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngr
ltaqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdp
avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
ksdfacanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wS (S:)
qqlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrl
taqfgitrkdsflnisasipsdvgiyfcagqplggsnykltfgkgtlltvnpniqnpdpa
vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
sdfacanafnnsiipedtffps

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >5w1wT (T:)
dsgvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgni
lerfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledln
kvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplk
eqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
awgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >5w1wT (T:)
gvtqtpkhlitatgqrvtlrcsprsgdlsvywyqqsldqglqfliqyyngeerakgnile
rfsaqqfpdlhselnlsslelgdsalyfcassanpgdssneklffgsgtqlsvledlnkv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra