PDB entry 5vkc

View 5vkc on RCSB PDB site
Description: Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
Class: signaling protein/inhibitor
Keywords: MCL-1, signaling protein-inhibitor complex
Deposited on 2017-04-21, released 2017-05-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-23, with a file datestamp of 2017-08-18.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d5vkca1, d5vkca2
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d5vkcb1, d5vkcb2
  • Heterogens: 9EA, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5vkcA (A:)
gsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >5vkcA (A:)
mdlyrqsleiisrylreqatgaksgatsrkaletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffhve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5vkcB (B:)
gsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >5vkcB (B:)
mdlyrqsleiisrylreqatgaksgatsrkaletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffhve