PDB entry 5v69

View 5v69 on RCSB PDB site
Description: Crystal structure of the Middle East respiratory syndrome coronavirus papain-like protease bound to ubiquitin variant ME.4
Class: hydrolase
Keywords: PLpro, ubiquitin, DUB, HYDROLASE
Deposited on 2017-03-16, released 2017-05-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MERS-CoV PLpro
    Species: Human betacoronavirus 2c EMC/2012 [TaxId:1235996]
    Gene: orf1ab
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5v69a1, d5v69a2
  • Chain 'B':
    Compound: me.4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5V69
    Domains in SCOPe 2.07: d5v69b_
  • Heterogens: ZN, CL, NA, PGO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5v69A (A:)
    tqqltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslylad
    nltadetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavim
    tldllkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakae
    lccsarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlve
    httpwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvs
    ktsdwkckvtdvlfpgqkyssdcn
    

    Sequence, based on observed residues (ATOM records): (download)
    >5v69A (A:)
    qqltievlvtvdgvnfrtvvlnnkntyrsqlgcvffngadisdtipdekqnghslyladn
    ltadetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimt
    ldllkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakael
    ccsarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlveh
    ttpwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvsk
    tsdwkckvtdvlfpgqkyssdc
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5v69B (B:)
    mahhhhhhvtslykkagstdykddddkmrifvetlrrltitlevepsdtienvkakiqdk
    egippdqqrliffgqqledgrtlsdynivkystlhlilrlnswy
    

    Sequence, based on observed residues (ATOM records): (download)
    >5v69B (B:)
    mrifvetltitlevepsdtienvkakiqdkegippdqqrliffgqqledgrtlsdynivk
    ystlhlilrlns