PDB entry 5v48

View 5v48 on RCSB PDB site
Description: Soluble rabbit neprilysin in complex with thiorphan
Class: hydrolase
Keywords: Neutral Endopeptidase, Proteinase, Zn-dependent, HYDROLASE
Deposited on 2017-03-08, released 2018-03-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neprilysin
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: MME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08049 (0-695)
      • variant (139)
      • variant (308)
      • conflict (312)
      • conflict (316)
    Domains in SCOPe 2.08: d5v48a_
  • Chain 'B':
    Compound: Neprilysin
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: MME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08049 (0-695)
      • variant (139)
      • variant (308)
      • conflict (312)
      • conflict (316)
    Domains in SCOPe 2.08: d5v48b_
  • Heterogens: ZN, TIO, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5v48A (A:)
gickssdciksaarliqnmdataepctdffkyacggwlkrnvipetssrysnfdilrdel
evilkdvlqepktedivavqkaktlyrscvnetaidsrggqpllkllpdvygwpvatqnw
eqtygtswsaeksiaqlnskygkkvlinffvgtddknsmnhiihidqprlglpsrdyyec
tgiykeactayvdfmiavaklirqeeglpidenqisvemnkvmelekeianattksedrn
dpmllynkmtlaqiqnnfsleingkpfswsnftneimstvninipneedvvvyapeylik
lkpiltkysprdlqnlmswrfimdlvsslsrtykdsrnafrkalygttsesatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkkaeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
witgaaivnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsannfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
igqayrayqnyvkkngeekllpgidlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigslqnsvefseafqcpknsymnpekkcrvw

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5v48B (B:)
gickssdciksaarliqnmdataepctdffkyacggwlkrnvipetssrysnfdilrdel
evilkdvlqepktedivavqkaktlyrscvnetaidsrggqpllkllpdvygwpvatqnw
eqtygtswsaeksiaqlnskygkkvlinffvgtddknsmnhiihidqprlglpsrdyyec
tgiykeactayvdfmiavaklirqeeglpidenqisvemnkvmelekeianattksedrn
dpmllynkmtlaqiqnnfsleingkpfswsnftneimstvninipneedvvvyapeylik
lkpiltkysprdlqnlmswrfimdlvsslsrtykdsrnafrkalygttsesatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkkaeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
witgaaivnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsannfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
igqayrayqnyvkkngeekllpgidlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigslqnsvefseafqcpknsymnpekkcrvw