PDB entry 5uwr
View 5uwr on RCSB PDB site
Description: Crystal Structure of CDC7 NES Peptide (extended) in complex with CRM1-Ran-RanBP1
Class: protein transport
Keywords: HEAT repeat, NES, nuclear export, Karyopherin, PROTEIN TRANSPORT
Deposited on
2017-02-21, released
2017-03-22
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-03-22, with a file datestamp of
2017-03-17.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTP-binding nuclear protein ran
Species: Homo sapiens [TaxId:9606]
Gene: RAN, ARA24, OK/SW-cl.81
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5uwra_ - Chain 'B':
Compound: Ran-specific GTPase-activating protein 1
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5uwrb_ - Chain 'C':
Compound: Exportin-1
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: CRM1, KAP124, XPO1, YGR218W, G8514
Database cross-references and differences (RAF-indexed):
- Uniprot P30822 (3-378)
- Uniprot P30822 (379-End)
- conflict (502)
- conflict (504-506)
- conflict (987)
- Chain 'D':
Compound: Cell division cycle 7-related protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: CDC7, CDC7L1
Database cross-references and differences (RAF-indexed):
- Heterogens: GNP, MG, GOL, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5uwrA (A:)
metgsshhhhhhssglprgshmaaqgepqvqfklvlvgdggtgkttfvkrhltgefekky
vatlgvevhplvfhtnrgpikfnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyk
nvpnwhrdlvrvcenipivlcgnkvdikdrkvkaksivfhrkknlqyydisaksnynfek
pflwlarkligdpnlefvampalappevvmdpalaaqyehdlevaqttalpdedddl
Sequence, based on observed residues (ATOM records): (download)
>5uwrA (A:)
vqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdtag
qekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdikd
rkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappeva
laaqyehdlevaqttalpdedddl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5uwrB (B:)
ggsdihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkk
tnkvrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairf
gskenadkfkeefekaqeinkka
Sequence, based on observed residues (ATOM records): (download)
>5uwrB (B:)
hfepvmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdktlk
icanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefek
aqeinkk
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.