PDB entry 5uqw

View 5uqw on RCSB PDB site
Description: Crystal structure of human KRAS G12V mutant in complex with GDP
Class: hydrolase
Keywords: KRAS, GTPase, HYDROLASE
Deposited on 2017-02-08, released 2017-03-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-03-22, with a file datestamp of 2017-03-17.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (20-End)
      • engineered mutation (31)
    Domains in SCOPe 2.06: d5uqwa_
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (20-End)
      • engineered mutation (31)
    Domains in SCOPe 2.06: d5uqwb_
  • Heterogens: MG, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5uqwA (A:)
    mgsshhhhhhssglvprgshmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsy
    rkqvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqi
    krvkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlv
    reirkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uqwA (A:)
    mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
    psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5uqwB (B:)
    mgsshhhhhhssglvprgshmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsy
    rkqvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqi
    krvkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlv
    reirkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >5uqwB (B:)
    mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtam
    rtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqd
    larsygipfietsaktrqgvddafytlvreirkhk