PDB entry 5uhn

View 5uhn on RCSB PDB site
Description: Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation
Class: transferase
Keywords: Tyrosine Kinase Domain Gain-of-Function ATP Analog Cell Surface Receptor, TRANSFERASE
Deposited on 2017-01-11, released 2017-02-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • conflict (46)
      • engineered mutation (104)
      • engineered mutation (120)
    Domains in SCOPe 2.08: d5uhna_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • conflict (46)
      • engineered mutation (104)
      • engineered mutation (120)
    Domains in SCOPe 2.08: d5uhnb_
  • Heterogens: SO4, ACP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uhnA (A:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniihllgactqdgplyviv
ayaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >5uhnA (A:)
pedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekdl
sdlvsememmkmigkhkniihllgactqdgplyvivayaskgnlreylrarreeqmtfkd
lvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttn
grlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrm
dkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uhnB (B:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniihllgactqdgplyviv
ayaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >5uhnB (B:)
pedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekdl
sdlvsememmkmigkhkniihllgactqdgplyvivayaskgnlreylrarrqmtfkdlv
sctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardigrlpvkwmapeal
fdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymm
mrdcwhavpsqrptfkqlvedldriltlt