PDB entry 5ufp
View 5ufp on RCSB PDB site
Description: Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex
Class: transcription
Keywords: HIF2 inhibitor HIF2 ligand PAS-B hypoxia inducible factor 2 EPAS1, TRANSCRIPTION
Deposited on
2017-01-05, released
2017-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Endothelial PAS domain-containing protein 1
Species: Homo sapiens [TaxId:9606]
Gene: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5ufpa_ - Chain 'B':
Compound: Aryl hydrocarbon receptor nuclear translocator
Species: Homo sapiens [TaxId:9606]
Gene: ARNT, BHLHE2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5ufpb_ - Heterogens: 86D, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5ufpA (A:)
geflgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtksh
qnlctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseie
Sequence, based on observed residues (ATOM records): (download)
>5ufpA (A:)
ldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtkshqnlct
kgqvvsgqyrmlakhggyvwletqgtviynppqcimcvnyvlse
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5ufpB (B:)
geflgnvcqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrd
sfqqvvklkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvkns
Sequence, based on observed residues (ATOM records): (download)
>5ufpB (B:)
cqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrdsfqqvvk
lkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvkns