PDB entry 5uc3

View 5uc3 on RCSB PDB site
Description: Structure of the dominant negative mutant Glucocorticoid Receptor alpha (L733K/N734P) complexed with RU-486
Class: hormone receptor
Keywords: Nuclear receptor, HORMONE RECEPTOR
Deposited on 2016-12-21, released 2017-12-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.01 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered mutation (212-213)
    Domains in SCOPe 2.08: d5uc3a_
  • Chain 'B':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered mutation (212-213)
    Domains in SCOPe 2.08: d5uc3b_
  • Heterogens: 486, MPD, EDO, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uc3A (A:)
spatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwaka
ipgfrnlhlddqmtllqyswmflmafalgwrsyrqssanllcfapdliineqrmtlpcmy
dqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgka
ivkregnssqnwqrfyqltklldsmhevvenlkpycfqtfldktmsiefpemlaeiitnq
ipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >5uc3A (A:)
pqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmflmafalgwrsyrqssanllcfapdliineqrmtlpcmydqckh
mlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkre
gnssqnwqrfyqltklldsmhevvenlkpycfqtfldktmsignikkllfhq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uc3B (B:)
spatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwaka
ipgfrnlhlddqmtllqyswmflmafalgwrsyrqssanllcfapdliineqrmtlpcmy
dqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgka
ivkregnssqnwqrfyqltklldsmhevvenlkpycfqtfldktmsiefpemlaeiitnq
ipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >5uc3B (B:)
pqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmflmafalgwrsyrqsanllcfapdliineqrmtlpcmydqckhm
lyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkreg
nssqnwqrfyqltklldsmhevvenlkpycfqtfldktmsignikkllfhq