PDB entry 5uaw

View 5uaw on RCSB PDB site
Description: Structure of apo human PYCR-1 crystallized in space group P21212
Class: oxidoreductase
Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Deposited on 2016-12-20, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uawa1, d5uawa2
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (16-21)
    Domains in SCOPe 2.08: d5uawb1, d5uawb2, d5uawb3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5uawc1, d5uawc2
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (19-21)
    Domains in SCOPe 2.08: d5uawd1, d5uawd2, d5uawd3
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (22-End)
      • expression tag (21)
    Domains in SCOPe 2.08: d5uawe1, d5uawe2, d5uawe3
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uawA (A:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uawA (A:)
svgfigagqlafalakgftaagvlaahkimasalrkmgvkltphnketvqhsdvlflavk
phiipfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvvvreg
atvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpayaftaldaladg
gvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatihalhvlesggfr
sllinaveascirtrelqsmadq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uawB (B:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uawB (B:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5uawC (C:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uawC (C:)
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpay
aftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatih
alhvlesggfrsllinaveascirtrelqsmadq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5uawD (D:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uawD (D:)
fqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnk
etvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprv
ircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsg
payaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgga
tihalhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5uawE (E:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >5uawE (E:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelqsmadqe