PDB entry 5twn

View 5twn on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: NS5B, POLYMERASE, HCV, FINGERS, PALM, THUMB, TRANSFERASE, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2016-11-14, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-10-31, with a file datestamp of 2018-10-26.
Experiment type: XRAY
Resolution: 3.04 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ns5b RNA- dependent RNA polymerase
    Species: Hepatitis C virus genotype 1b (isolate Con1) [TaxId:333284]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5twna_
  • Chain 'B':
    Compound: ns5b RNA- dependent RNA polymerase
    Species: Hepatitis C virus genotype 1b (isolate Con1) [TaxId:333284]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5twnb_
  • Heterogens: 23E, SO4, 7NG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5twnA (A:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5twnA (A:)
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrvef
lvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyig
gpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvi
cesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyy
ltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekal
dcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhr
arsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhs
lsrarprwfm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5twnB (B:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5twnB (B:)
smsytwtgalitpcyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakll
sveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakne
vfcvqpkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrveflvnaw
kakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyiggpltn
skgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvicesag
tqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyyltrdp
ttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekaldcqiy
gacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhrarsvr
arllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhsl