PDB entry 5tru
View 5tru on RCSB PDB site
Description: Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4
Class: immune system
Keywords: antibody, complex, Fab, IMMUNE SYSTEM
Deposited on
2016-10-27, released
2017-05-10
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-05-24, with a file datestamp of
2017-05-19.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'C':
Compound: cytotoxic t-lymphocyte protein 4
Species: Homo sapiens [TaxId:9606]
Gene: CTLA4, CD152
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5truc_ - Chain 'H':
Compound: Ipilimumab Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Ipilimumab Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5trul1, d5trul2 - Chain 'c':
Compound: cytotoxic t-lymphocyte protein 4
Species: Homo sapiens [TaxId:9606]
Gene: CTLA4, CD152
Database cross-references and differences (RAF-indexed):
- Chain 'h':
Compound: Ipilimumab Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'l':
Compound: Ipilimumab Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
PDB Chain Sequences:
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5truC (C:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidp
Sequence, based on observed residues (ATOM records): (download)
>5truC (C:)
amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
fdsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvi
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>5truL (L:)
eivltqspgtlslspgeratlscrasqsvgssylawyqqkpgqaprlliygafsratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>5truL (L:)
eivltqspgtlslspgeratlscrasqsvgssylawyqqkpgqaprlliygafsratgip
drfsgsgsgtdftltisrlepedfavyycqqygsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrg
- Chain 'c':
No sequence available.
- Chain 'h':
No sequence available.
- Chain 'l':
No sequence available.