PDB entry 5tru

View 5tru on RCSB PDB site
Description: Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4
Class: immune system
Keywords: antibody, complex, Fab, IMMUNE SYSTEM
Deposited on 2016-10-27, released 2017-05-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-07, with a file datestamp of 2017-06-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5truc_
  • Chain 'H':
    Compound: Ipilimumab Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TRU (0-End)
  • Chain 'L':
    Compound: Ipilimumab Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TRU (0-End)
    Domains in SCOPe 2.07: d5trul1, d5trul2
  • Chain 'c':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed):
  • Chain 'h':
    Compound: Ipilimumab Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TRU (0-End)
  • Chain 'l':
    Compound: Ipilimumab Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5TRU (0-End)

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5truC (C:)
    amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
    flddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidp
    

    Sequence, based on observed residues (ATOM records): (download)
    >5truC (C:)
    amhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgnelt
    fdsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvi
    

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >5truL (L:)
    eivltqspgtlslspgeratlscrasqsvgssylawyqqkpgqaprlliygafsratgip
    drfsgsgsgtdftltisrlepedfavyycqqygsspwtfgqgtkveikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >5truL (L:)
    eivltqspgtlslspgeratlscrasqsvgssylawyqqkpgqaprlliygafsratgip
    drfsgsgsgtdftltisrlepedfavyycqqygsspwtfgqgtkveikrtvaapsvfifp
    psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
    tlskadyekhkvyacevthqglsspvtksfnrg
    

  • Chain 'c':
    No sequence available.

  • Chain 'h':
    No sequence available.

  • Chain 'l':
    No sequence available.