PDB entry 5trj

View 5trj on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-3-[(4-chlorophenyl)methoxy]benzoic acid
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: NS5B, POLYMERASE, HCV, FINGERS, PALM, THUMB, TRANSFERASE, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on 2016-10-26, released 2016-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-01-11, with a file datestamp of 2017-01-06.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-dependent RNA polymerase
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5trja_
  • Chain 'B':
    Compound: RNA-dependent RNA polymerase
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5trjb_
  • Heterogens: 23E, 7HO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5trjA (A:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5trjA (A:)
smsytwtgalitpcvyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakn
evfcvqpekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrve
flvnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyi
ggpltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvv
icesagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvy
yltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqleka
ldcqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrh
rarsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyh
slsrarprwfm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5trjB (B:)
msmsytwtgalitpcaaeetklpinalsnsllrhhnlvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsarskfgygakdvrnlsskavnhi
rsvwkdlledtetpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspgqrveflvnawkakkcpmgfaydtrcfdstvtendirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
aaacraaklqdctmlvcgddlvvicesagtqedeaslrafteamtrysappgdppkpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiiqrlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavrtklkltpi
paasqldlsswfvagysggdiyhslsrarprwfm

    Sequence, based on observed residues (ATOM records): (download) 
    >5trjB (B:)
smsytwtgalitpcvyattsrsaslrqkkvtfdrlqvlddhyrdvlkemkakastvkakl
lsveeackltpphsarskfgygakdvrnlsskavnhirsvwkdlledtetpidttimakn
evfcvekggrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfqyspgqrvefl
vnawkakkcpmgfaydtrcfdstvtendirveesiyqccdlapearqairslterlyigg
pltnskgqncgyrrcrasgvlttscgntltcylkaaaacraaklqdctmlvcgddlvvic
esagtqedeaslrafteamtrysappgdppkpeydlelitscssnvsvahdasgkrvyyl
trdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeqlekald
cqiygacysiepldlpqiiqrlhglsafslhsyspgeinrvasclrklgvpplrvwrhra
rsvrarllsqggraatcgkylfnwavrtklkltpipaasqldlsswfvagysggdiyhsl
sra