PDB entry 5tqe
View 5tqe on RCSB PDB site
Description: Factor VIIa in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione
Class: hydrolase/hydrolase inhibitor
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2016-10-24, released
2017-02-01
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-02-01, with a file datestamp of
2017-01-26.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Factor VIIa (Heavy Chain)
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5tqeh_ - Chain 'L':
Compound: Factor VIIa (Light Chain)
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5tqel_ - Heterogens: 7KQ, CA, SO4, GOL, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>5tqeH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
Sequence, based on observed residues (ATOM records): (download)
>5tqeH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkdspniteymfcagysd
gskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrse
prpgvllrapfp
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>5tqeL (L:)
icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr