PDB entry 5tq6

View 5tq6 on RCSB PDB site
Description: Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Class: Transferase/Transferase Inhibitor
Keywords: Kinase, Inflammation, Jak Inhibitor, Transferase-Transferase Inhibitor complex
Deposited on 2016-10-23, released 2017-01-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-02-08, with a file datestamp of 2017-02-03.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (Start-303)
      • engineered mutation (244)
      • engineered mutation (247)
    Domains in SCOPe 2.08: d5tq6a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674
      • engineered mutation (244)
      • engineered mutation (247)
    Domains in SCOPe 2.08: d5tq6b_
  • Heterogens: 7GV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tq6A (A:)
mghhhhhhedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhst
eehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeri
dhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyy
kvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmignd
kqgqsivthliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird
nmag

    Sequence, based on observed residues (ATOM records): (download) 
    >5tq6A (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkespifwyapesltes
kfsvasdvwsfgvvlyelftyieksksppaefmrmisivthliellknngrlprpdgcpd
eiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5tq6B (B:)
mghhhhhhedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhst
eehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeri
dhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyy
kvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmignd
kqgqsivthliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqird
nmag

    Sequence, based on observed residues (ATOM records): (download) 
    >5tq6B (B:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkspifwyapesltesk
fsvasdvwsfgvvlyelftyieksksppaefmrmisivthliellknngrlprpdgcpde
iymimtecwnnnvnqrpsfrdlalrvdqirdnm