PDB entry 5tn9
View 5tn9 on RCSB PDB site
Description: Crystal Structure of the ER-alpha Ligand-binding Domain (L372S,L536S) in Complex with the OBHS-BSC, 4-bromophenyl (1R,2R,4S)-5-(4-hydroxyphenyl)-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate
Class: transcription
Keywords: Nuclear receptor, transcription factor, ligand binding, protein-ligand complex, TRANSCRIPTION
Deposited on
2016-10-13, released
2017-02-15
The last revision prior to the SCOPe 2.06 freeze date was dated
2017-02-15, with a file datestamp of
2017-02-10.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
- engineered mutation (74)
- engineered mutation (238)
Domains in SCOPe 2.06: d5tn9a_ - Chain 'B':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
- engineered mutation (74)
- engineered mutation (238)
Domains in SCOPe 2.06: d5tn9b_ - Chain 'C':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
- engineered mutation (74)
- engineered mutation (238)
Domains in SCOPe 2.06: d5tn9c_ - Chain 'D':
Compound: Estrogen receptor
Species: Homo sapiens [TaxId:9606]
Gene: ESR1, ESR, NR3A1
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
- engineered mutation (74)
- engineered mutation (238)
Domains in SCOPe 2.06: d5tn9d_ - Heterogens: 7EC, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5tn9A (A:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsy
dlllemldahrlhapts
Sequence, based on observed residues (ATOM records): (download)
>5tn9A (A:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnmveifdmllats
srfrmmnlqgeefvclksiillnsgvytfsleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehknvvpsydlllemlda
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5tn9B (B:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsy
dlllemldahrlhapts
Sequence, based on observed residues (ATOM records): (download)
>5tn9B (B:)
slalsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltshd
qvhllecawleilmiglvwrsmehpgkllfapnllldrnqgmveifdmllatssrfrmmn
lqgeefvclksiillnsgveekdhihrvldkitdtlihlmakagltlqqqhqrlaqllli
lshirhmsnkgmehlysvvpsydlllemlda
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5tn9C (C:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsy
dlllemldahrlhapts
Sequence, based on observed residues (ATOM records): (download)
>5tn9C (C:)
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnmveifdmllatss
rfrmmnlqgeefvclksiillnsgvytflksleekdhihrvldkitdtlihlmakagltl
qqqhqrlaqlllilshirhmsnkgmehlysvvpsydlllemlda
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5tn9D (D:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsy
dlllemldahrlhapts
Sequence, based on observed residues (ATOM records): (download)
>5tn9D (D:)
slalsltadqmvsalldaeppilyseydsmmglltnladrelvhminwakrvpgfvdlts
hdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgmveifdmllatssrfrm
mnlqgeefvclksiillnsgvytstlksleekdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlyvpsydlllemlda