PDB entry 5tl7

View 5tl7 on RCSB PDB site
Description: Crystal structure of SARS-CoV papain-like protease in complex with C-terminal domain mouse ISG15
Class: Signaling protein/Hydrolase
Keywords: Signaling protein, Hydrolase, Signaling protein-Hydrolase complex
Deposited on 2016-10-10, released 2017-05-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.44 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin-like protein ISG15
    Species: Mus musculus [TaxId:10090]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q64339 (Start-78)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tl7a_
  • Chain 'B':
    Compound: Replicase polyprotein 1ab
    Species: SARS coronavirus [TaxId:227859]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6X7 (4-318)
      • expression tag (3)
    Domains in SCOPe 2.07: d5tl7b1, d5tl7b2, d5tl7b3
  • Chain 'C':
    Compound: Ubiquitin-like protein ISG15
    Species: Mus musculus [TaxId:10090]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q64339 (Start-78)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tl7c_
  • Chain 'D':
    Compound: Replicase polyprotein 1ab
    Species: SARS coronavirus [TaxId:227859]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5tl7d1, d5tl7d2
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5tl7A (A:)
    meplsilvrnerghsniyevfltqtvdtlkkkvsqreqvhedqfwlsfegrpmedkellg
    eyglkpqctvikhlrlrgx
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl7A (A:)
    plsilvrnerghsniyevfltqtvdtlkkkvsqreqvhedqfwlsfegrpmedkellgey
    glkpqctvikhlrlrgx
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5tl7B (B:)
    masmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktff
    vlpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssv
    llalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqha
    nlesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvq
    qessfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmsey
    kgpvtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl7B (B:)
    mevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlp
    sddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvlla
    lqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanle
    sakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqes
    sfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgp
    vtdvfyketsytttik
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5tl7C (C:)
    meplsilvrnerghsniyevfltqtvdtlkkkvsqreqvhedqfwlsfegrpmedkellg
    eyglkpqctvikhlrlrgx
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl7C (C:)
    plsilvrnerghsniyevfltqtvdtlkkkvsqreqvhedqfwlsfegrpmedkellgey
    glkpqctvikhlrlrgx
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5tl7D (D:)
    masmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktff
    vlpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssv
    llalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqha
    nlesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvq
    qessfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmsey
    kgpvtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl7D (D:)
    ktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlpsdd
    tlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvllalqq
    levkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanlesak
    rvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqessfv
    mmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgpvtd
    vfyketsytttik