PDB entry 5tl6

View 5tl6 on RCSB PDB site
Description: Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15
Class: Signaling protein/hydrolase
Keywords: Signaling protein, hydrolase, Signaling protein-hydrolase complex
Deposited on 2016-10-10, released 2017-05-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin-like protein ISG15
    Species: Homo sapiens [TaxId:9606]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05161 (1-78)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tl6a_
  • Chain 'B':
    Compound: Replicase polyprotein 1ab
    Species: Human SARS coronavirus [TaxId:227859]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5tl6b1, d5tl6b2
  • Chain 'C':
    Compound: Ubiquitin-like protein ISG15
    Species: Homo sapiens [TaxId:9606]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05161 (1-78)
      • initiating methionine (0)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tl6c_
  • Chain 'D':
    Compound: Replicase polyprotein 1ab
    Species: Human SARS coronavirus [TaxId:227859]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5tl6d1, d5tl6d2
  • Heterogens: ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5tl6A (A:)
    meplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplg
    eyglkplstvfmnlrlrgx
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl6A (A:)
    eplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplge
    yglkplstvfmnlrlrgx
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5tl6B (B:)
    masmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktff
    vlpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssv
    llalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqha
    nlesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvq
    qessfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmsey
    kgpvtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl6B (B:)
    evktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlps
    ddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvllal
    qqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanles
    akrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqess
    fvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgpv
    tdvfyketsytttik
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5tl6C (C:)
    meplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlplg
    eyglkplstvfmnlrlrgx
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5tl6D (D:)
    masmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktff
    vlpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssv
    llalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqha
    nlesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvq
    qessfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmsey
    kgpvtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >5tl6D (D:)
    tikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlpsddt
    lrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvllalqql
    evkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanlesakr
    vlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqessfvm
    msappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgpvtdv
    fyketsytttik