PDB entry 5tks
View 5tks on RCSB PDB site
Description: factor xia in complex with the inhibitor ((15s)-18-chloro- 15-(((2e)-3-(5-chloro-2-(1h-tetrazol-1-yl)phenyl)-2- propenoyl)amino)-17,19-diazatricyclo[14.2.1.0~2,7~]nonadeca-1(18),2,4,6,16(19)-pentaen-5-yl)carbamate
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, hydrolase-hydrolase inhibitor complex
Deposited on
2016-10-07, released
2017-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-03-01, with a file datestamp of
2017-02-24.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Coagulation factor XI
Species: Homo sapiens [TaxId:9606]
Gene: F11
Database cross-references and differences (RAF-indexed):
- Uniprot P03951 (0-237)
- engineered mutation (103)
- engineered mutation (105)
Domains in SCOPe 2.08: d5tksa_ - Heterogens: 7DL, SO4, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5tksA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqseikedtsffgvqeiiihdqykmaesgydiallklettvgygdsqrpiclpskgdr
nviytdcwvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyregg
kdackgdsggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektqavhh
hhhh
Sequence, based on observed residues (ATOM records): (download)
>5tksA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqseikedtsffgvqeiiihdqykmaesgydiallklettvgygdsqrpiclpskgdr
nviytdcwvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyregg
kdackgdsggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektqav