PDB entry 5tdi

View 5tdi on RCSB PDB site
Description: Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.
Class: hydrolase/hydrolase inhibitor
Keywords: cathepsin K, covalent, inhibitor, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2016-09-19, released 2017-01-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: cathepsin k
  Species: Homo sapiens [TaxId:9606]
  Gene: CTSK, CTSO, CTSO2
  Database cross-references and differences (RAF-indexed):
  • Uniprot P43235 (0-214)
    • engineered mutation (48)
  Domains in SCOPe 2.08: d5tdia_
• Heterogens: 7AS, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5tdiA (A:)
  apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlapqnlvdcvsen
  dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
  lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
  knswgenwgnkgyilmarnknnacgianlasfpkm