PDB entry 5tc4
View 5tc4 on RCSB PDB site
Description: Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors
Class: oxidoreductase
Keywords: Inhibitor, Folate, Cofactor, Dehydrogenase, Oxidoreductase
Deposited on
2016-09-14, released
2016-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-09-13, with a file datestamp of
2017-09-08.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: MTHFD2, NMDMC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5tc4a1, d5tc4a2 - Heterogens: NAD, L34, PO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5tc4A (A:)
meavvisgrklaqqikqevrqeveewvasgnkrphlsvilvgenpashsyvlnktraaav
vginsetimkpasiseeellnlinklnnddnvdgllvqlplpehiderricnavspdkdv
dgfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgknvvvagrsknvgmpiamllh
tdgaherpggdatvtishrytpkeqlkkhtiladivisaagipnlitadmikegaavidv
ginrvhdpvtakpklvgdvdfegvrqkagyitpvpggvgpmtvamlmkntiiaakkvlrl
eerevlkskelgvatn
Sequence, based on observed residues (ATOM records): (download)
>5tc4A (A:)
eavvisgrklaqqikqevrqeveewvasgnkrphlsvilvgenpashsyvlnktraaavv
ginsetimkpasiseeellnlinklnnddnvdgllvqlplpehiderricnavspdkdvd
gfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgknvvvagrsknvgmpiamllht
dgaherpggdatvtishrytpkeqlkkhtiladivisaagipnlitadmikegaavidvg
inrvhkpklvgdvdfegvrqkagyitpvpggvgpmtvamlmkntiiaakkvl