PDB entry 5ta6

View 5ta6 on RCSB PDB site
Description: Crystal structure of PLK1 in complex with a novel 5,6-dihydroimidazolo[1,5-f]pteridine inhibitor.
Class: Transferase/Transferase Inhibitor
Keywords: PLK1 Inhibitor, Kinase, Structure-based drug design, Antitumor activity, Transferase-Transferase Inhibitor complex
Deposited on 2016-09-09, released 2017-02-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P53350
      • conflict (222)
    Domains in SCOPe 2.08: d5ta6a_
  • Heterogens: 79D, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ta6A (A:)
msyyhhhhhhdydipttenlyfqgaapadpgkagvpgvaapgapaaappakeipevlvdp
rsrrryvrgrflgkggfakcfeisdadtkevfagkivpkslllkphqrekmsmeisihrs
lahqhvvgfhgffedndfvfvvlelcrrrsllelhkrrkaltepearyylrqivlgcqyl
hrnrvihrdlklgnlflnedlevkigdfglatkveydgerkkvlcgtpnyiapevlskkg
hsfevdvwsigcimytllvgkppfetsclketylrikkneysipkhinpvaasliqkmlq
tdptarptinellndefftsgyiparlpitcltipprfsiapssldpsnrkpltvlnk

    Sequence, based on observed residues (ATOM records): (download) 
    >5ta6A (A:)
akeipevlvdprsrrryvrgrflgkggfakcfeisdadtkevfagkivpkslllkphqre
kmsmeisihrslahqhvvgfhgffedndfvfvvlelcrrrsllelhkrrkaltepearyy
lrqivlgcqylhrnrvihrdlklgnlflnedlevkigdfglatkveydgerkkvlcgtpn
yiapevlskkghsfevdvwsigcimytllvgkppfetsclketylrikkneysipkhinp
vaasliqkmlqtdptarptinellndefftsgyiparlpitcltipprfsiaps