PDB entry 5t6n

View 5t6n on RCSB PDB site
Description: Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with the antiviral drug arbidol
Class: viral protein
Keywords: Viral protein, Ectodomain, N-glycosylation, antiviral
Deposited on 2016-09-01, released 2017-01-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hemagglutinin HA1
    Species: Influenza A virus (strain A/Hong Kong/1/1968 H3N2) [TaxId:506350]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91MA7 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d5t6na1, d5t6na2
  • Chain 'B':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (strain A/Northern Territory/60/1968 H3N2) [TaxId:384505]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03436 (0-End)
      • conflict (122)
    Domains in SCOPe 2.08: d5t6nb_
  • Chain 'C':
    Compound: hemagglutinin HA1
    Species: Influenza A virus (strain A/Hong Kong/1/1968 H3N2) [TaxId:506350]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91MA7 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d5t6nc1, d5t6nc2
  • Chain 'D':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (strain A/Northern Territory/60/1968 H3N2) [TaxId:384505]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03436 (0-End)
      • conflict (122)
    Domains in SCOPe 2.08: d5t6nd_
  • Chain 'E':
    Compound: hemagglutinin HA1
    Species: Influenza A virus (strain A/Hong Kong/1/1968 H3N2) [TaxId:506350]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91MA7 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d5t6ne1, d5t6ne2
  • Chain 'F':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (strain A/Northern Territory/60/1968 H3N2) [TaxId:384505]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03436 (0-End)
      • conflict (122)
    Domains in SCOPe 2.08: d5t6nf_
  • Heterogens: NAG, 75U, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5t6nA (A:)
adpgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctl
idallgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegft
wtgvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhps
tnqeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvin
sngnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacp
kyvkqntlklatgmrnvpekqtr

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nA (A:)
pgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctlid
allgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegftwt
gvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhpstn
qeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvinsn
gnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacpky
vkqntlklatgmrnvpek

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5t6nB (B:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrfqik

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nB (B:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrfq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5t6nC (C:)
adpgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctl
idallgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegft
wtgvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhps
tnqeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvin
sngnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacp
kyvkqntlklatgmrnvpekqtr

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nC (C:)
pgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctlid
allgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegftwt
gvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhpstn
qeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvinsn
gnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacpky
vkqntlklatgmrnvpe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5t6nD (D:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrfqik

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nD (D:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5t6nE (E:)
adpgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctl
idallgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegft
wtgvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhps
tnqeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvin
sngnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacp
kyvkqntlklatgmrnvpekqtr

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nE (E:)
pgatlclghhavpngtlvktitddqievtnatelvqssstgkicnnphrildgidctlid
allgdphcdvfqnetwdlfverskafsncypydvpdyaslrslvassgtlefitegftwt
gvtqnggsnackrgpgsgffsrlnwltksgstypvlnvtmpnndnfdklyiwgvhhpstn
qeqtslyvqasgrvtvstrrsqqtiipnigsrpwvrglssrisiywtivkpgdvlvinsn
gnliaprgyfkmrtgkssimrsdapidtcisecitpngsipndkpfqnvnkitygacpky
vkqntlklatgmrnvpek

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5t6nF (F:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrfqik

    Sequence, based on observed residues (ATOM records): (download) 
    >5t6nF (F:)
glfgaiagfiengwegmidgwygfrhqnsegtgqaadlkstqaaidqingklnrviektn
ekfhqiekefsevegriqdlekyvedtkidlwsynaellvalenqhtidltdsemnklfe
ktgrqlrenaedmgngcfkiyhkcdnaciesirngtydhdvyrdealnnrf