PDB entry 5sxp

View 5sxp on RCSB PDB site
Description: structural basis for the interaction between itch prr and beta-pix
Class: signaling protein/ligase
Keywords: SH3 DOMAIN PEPTIDE LIGAND COMPLEX, LIGASE, SIGNALING PROTEIN-LIGASE complex
Deposited on 2016-08-09, released 2017-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5sxpa_
  • Chain 'B':
    Compound: Rho guanine nucleotide exchange factor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5sxpb_
  • Chain 'C':
    Compound: Rho guanine nucleotide exchange factor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5sxpc_
  • Chain 'D':
    Compound: Rho guanine nucleotide exchange factor 7
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5sxpd_
  • Chain 'F':
    Compound: E3 ubiquitin-protein ligase Itchy homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: ITCH
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: E3 ubiquitin-protein ligase Itchy homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: ITCH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96J02 (5-End)
      • expression tag (4)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5sxpA (A:)
    gsnnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrev
    ka
    

    Sequence, based on observed residues (ATOM records): (download)
    >5sxpA (A:)
    snnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrevk
    a
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5sxpB (B:)
    gsnnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrev
    ka
    

    Sequence, based on observed residues (ATOM records): (download)
    >5sxpB (B:)
    snnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrevk
    a
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5sxpC (C:)
    gsnnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrev
    ka
    

    Sequence, based on observed residues (ATOM records): (download)
    >5sxpC (C:)
    nnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrevka
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5sxpD (D:)
    gsnnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrev
    ka
    

    Sequence, based on observed residues (ATOM records): (download)
    >5sxpD (D:)
    nnqlvvrakfnfqqtnedelsfskgdvihvtrveeggwwegtlngrtgwfpsnyvrevka
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.