PDB entry 5svn

View 5svn on RCSB PDB site
Description: Structure of IDH2 mutant R172K
Class: oxidoreductase
Keywords: inhibitor, isocitrate dehydrogenase, MITOCHONDRIAL, NADPH, OXIDOREDUCTASE
Deposited on 2016-08-06, released 2017-02-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-02-08, with a file datestamp of 2017-02-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP], mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48735
      • engineered mutation (132)
    Domains in SCOPe 2.06: d5svna_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP], mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48735
      • engineered mutation (132)
    Domains in SCOPe 2.06: d5svnb_
  • Heterogens: NDP, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5svnA (A:)
adkrikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtid
salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
lvpgwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgm
gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfd
knkiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmle
kvcvetvesgamtkdlagcihglsnvklnehflnttdfldtiksnldralgrqslehhhh
hhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5svnA (A:)
rikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtidsal
atqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiickniprlvp
gwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgmgmy
ntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfdknk
iwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdgkti
eaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmlekvc
vetvesgamtkdlagcihgflnttdfldtiksnldralg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5svnB (B:)
adkrikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtid
salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
lvpgwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgm
gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfd
knkiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmle
kvcvetvesgamtkdlagcihglsnvklnehflnttdfldtiksnldralgrqslehhhh
hhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5svnB (B:)
rikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtidsal
atqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiickniprlvp
gwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgmgmy
ntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfdknk
iwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdgkti
eaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmlekvc
vetvesgamtkdlagcihglsnlnehflnttdfldtiksnldralgr