PDB entry 5svn

View 5svn on RCSB PDB site
Description: Structure of IDH2 mutant R172K
Class: oxidoreductase
Keywords: inhibitor, isocitrate dehydrogenase, MITOCHONDRIAL, NADPH, OXIDOREDUCTASE
Deposited on 2016-08-06, released 2017-02-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-03-22, with a file datestamp of 2017-03-17.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP], mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48735
      • engineered mutation (132)
    Domains in SCOPe 2.07: d5svna_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP], mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48735
      • engineered mutation (132)
    Domains in SCOPe 2.07: d5svnb_
  • Heterogens: NDP, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5svnA (A:)
    adkrikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtid
    salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
    lvpgwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgm
    gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfd
    knkiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
    ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmle
    kvcvetvesgamtkdlagcihglsnvklnehflnttdfldtiksnldralgrqslehhhh
    hhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5svnA (A:)
    rikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtidsal
    atqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiickniprlvp
    gwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgmgmy
    ntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfdknk
    iwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdgkti
    eaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmlekvc
    vetvesgamtkdlagcihgflnttdfldtiksnldralg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5svnB (B:)
    adkrikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtid
    salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
    lvpgwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgm
    gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfd
    knkiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
    ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmle
    kvcvetvesgamtkdlagcihglsnvklnehflnttdfldtiksnldralgrqslehhhh
    hhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5svnB (B:)
    rikvakpvvemdgdemtriiwqfikeklilphvdiqlkyfdlglpnrdqtddqvtidsal
    atqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiickniprlvp
    gwtkpitigkhahgdqykatdfvadragtfkmvftpkdgsgvkewevynfpaggvgmgmy
    ntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifdkhyktdfdknk
    iwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdgkti
    eaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqmlekvc
    vetvesgamtkdlagcihglsnlnehflnttdfldtiksnldralgr