PDB entry 5qu0

View 5qu0 on RCSB PDB site
Description: tgf-beta receptor type 1 kinase domain (t204d) in complex with 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1h-imidazol-5-yl]imidazo[1,2-b]pyridazine-3-carbonitrile
Class: transferase
Keywords: alk5, kinase domain, transferase-transferase inhibitor complex, transferase
Deposited on 2019-11-19, released 2020-02-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1, ALK5, SKR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36897 (3-End)
      • expression tag (0-2)
      • engineered mutation (7)
    Domains in SCOPe 2.07: d5qu0a1, d5qu0a2
  • Heterogens: QMV, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5qu0A (A:)
ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
qqegikm

    Sequence, based on observed residues (ATOM records): (download) 
    >5qu0A (A:)
ghmtiardivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrh
enilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahl
hmeivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtk
rymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdp
sveemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls
qqegik