PDB entry 5p8w
View 5p8w on RCSB PDB site
Description: Crystal Structure of COMT in complex with [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine
Class: transferase
Keywords: methyltransferase, neurotransmitter degradation, transferase
Deposited on
2016-08-25, released
2016-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-02-21, with a file datestamp of
2018-02-16.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- engineered mutation (90)
- engineered mutation (94)
Domains in SCOPe 2.08: d5p8wa_ - Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- engineered mutation (90)
- engineered mutation (94)
Domains in SCOPe 2.08: d5p8wb_ - Chain 'C':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- engineered mutation (90)
- engineered mutation (94)
Domains in SCOPe 2.08: d5p8wc_ - Heterogens: DTT, O01, FMT, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5p8wA (A:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5p8wA (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgps
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5p8wB (B:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5p8wB (B:)
dtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspslv
lelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdl
ipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflay
vrgsssfecthyssyleymkvvdglekaiyqgp
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5p8wC (C:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5p8wC (C:)
dtkeqrilryvqqnakpgdpqsvleaidtyctqkamnvgdakgqimdavireyspslvle
lgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdlip
qlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflayvr
gsssfecthyssyleymkvvdglekaiyqgps