PDB entry 5oq7

View 5oq7 on RCSB PDB site
Description: Structure of CHK1 8-pt. mutant complex with arylbenzamide LRRK2 inhibitor
Class: transferase
Keywords: Parkinson's disease, Leucine-rich repeat kinase 2, LRRK2, Checkpoint kinase 1, CHK1, mutant, surrogate, kinase inhibitor, TRANSFERASE
Deposited on 2017-08-10, released 2017-10-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase Chk1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHEK1, CHK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14757
      • engineered mutation (58)
      • engineered mutation (67)
      • engineered mutation (83)
      • engineered mutation (85-86)
      • engineered mutation (90)
      • engineered mutation (133)
      • engineered mutation (146)
    Domains in SCOPe 2.06: d5oq7a_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase Chk1
    Species: Homo sapiens [TaxId:9606]
    Gene: CHEK1, CHK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14757
      • engineered mutation (58)
      • engineered mutation (67)
      • engineered mutation (83)
      • engineered mutation (85-86)
      • engineered mutation (90)
      • engineered mutation (133)
      • engineered mutation (146)
    Domains in SCOPe 2.06: d5oq7b_
  • Heterogens: A0Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5oq7A (A:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilk
mlnhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikphnlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsghhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5oq7A (A:)
dwdlvqtlgegaygevqlavnrvteeavavkivdmcpenikkeicilkmlnhenvikfyg
hrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdik
phnlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvw
scgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsa
ritipdikkdrwynkplkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5oq7B (B:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilk
mlnhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikphnlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsghhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5oq7B (B:)
dwdlvqtlgeggevqlavnrvteeavavkivdmcpenikkeicilkmlnhenvikfyghr
regniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdikph
nlllderdnlkiadfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwsc
givltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsari
tipdikkdrwynkplk