PDB entry 5o74

View 5o74 on RCSB PDB site
Description: Crystal structure of human Rab1b covalently bound to the GEF domain of DrrA/SidM from Legionella pneumophila in the presence of GDP
Class: hydrolase
Keywords: Rab1b, DrrA, exchange factor, Legionella pneumophila, hydrolase
Deposited on 2017-06-08, released 2017-10-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3
      • engineered mutation (175)
  • Chain 'B':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74b_
  • Chain 'C':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3
      • engineered mutation (175)
  • Chain 'D':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74d_
  • Chain 'E':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3
      • engineered mutation (175)
  • Chain 'F':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74f_
  • Chain 'G':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3
      • engineered mutation (175)
  • Chain 'H':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74h_
  • Chain 'I':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3 (3-End)
      • expression tag (2)
      • engineered mutation (175)
  • Chain 'J':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74j_
  • Chain 'K':
    Compound: Multifunctional virulence effector protein DrrA
    Species: Legionella pneumophila [TaxId:446]
    Gene: drrA, sidM
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q29ST3
      • engineered mutation (175)
  • Chain 'L':
    Compound: Ras-related protein Rab-1B
    Species: Homo sapiens [TaxId:9606]
    Gene: RAB1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9H0U4
      • engineered mutation (78)
    Domains in SCOPe 2.08: d5o74l_
  • Heterogens: GDP

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5o74B (B:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74B (B:)
eydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklqiwd
tagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvgnks
dlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5o74D (D:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74D (D:)
eydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklqiwd
tagqerfrtyxgahgiivvydvtdqesyanvkqwlqeidryvnkllvgnksdlttkkvvd
nttakefadslgipfletsaknatnveqafmtmaaeikkrm

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5o74F (F:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74F (F:)
eydylfkllligdsgvgksclllrfaesyistigvdfkirtieldgktiklqiwdtagqe
rfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvgnksdlttk
kvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrm

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5o74H (H:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74H (H:)
eydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklqiwd
tagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvgnks
dlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrm

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >5o74J (J:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74J (J:)
eydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklqiwd
tagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvgnkk
vvdnttakefadslgipfletsaknatnveqafmtmaaeikkrm

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5o74L (L:)
mapeydylfkllligdsgvgksclllrfaddtytesyistigvdfkirtieldgktiklq
iwdtagqerfrtitssyyxgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvg
nksdlttkkvvdnttakefadslgipfletsaknatnveqafmtmaaeikkrmghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5o74L (L:)
eydylfkllligdsgvgksclllristigvdfkirtieldgktiklqiwdtagqerfrty
xgahgiivvydvtdqesyanvkqwlqeidryasenvnkllvgnksdlkvvdnttakefad
slgipfletsaknatnveqafmtmaaeikkrm