PDB entry 5ntt

View 5ntt on RCSB PDB site
Description: Crystal structure of human Mps1 (TTK) C604Y mutant in complex with NMS-P715
Class: transferase
Keywords: Mps1, TTK, kinase, inhibitor, NMS-P715, mutant, C604Y, transferase
Deposited on 2017-04-28, released 2017-07-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-13, with a file datestamp of 2017-09-08.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (8-286)
      • expression tag (0-7)
      • engineered mutation (93)
    Domains in SCOPe 2.08: d5ntta1, d5ntta2
  • Heterogens: SVE, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nttA (A:)
enlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrn
eiaylnklqqhsdkiirlydyeitdqyiymvmeygnidlnswlkkkksidpwerksywkn
mleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnym
ppeaikdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidp
nheiefpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqthp

    Sequence, based on observed residues (ATOM records): (download) 
    >5nttA (A:)
enlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrn
eiaylnklqqhsdkiirlydyeitdqyiymvmeygnidlnswlkkkksidpwerksywkn
mleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnym
ppeaikdmskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdip
ekdlqdvlkcclkrdpkqrisipellahpyvqiqthp