PDB entry 5ntq

View 5ntq on RCSB PDB site
Description: Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Class: signaling protein
Keywords: nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein
Deposited on 2017-04-28, released 2017-06-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-19, with a file datestamp of 2017-07-14.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (193)
    Domains in SCOPe 2.07: d5ntqa_
  • Chain 'B':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449
      • engineered mutation (193)
    Domains in SCOPe 2.07: d5ntqb_
  • Heterogens: 444, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ntqA (A:)
    gpyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerca
    hhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegk
    yggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveq
    lqynlelafhhhlskthrqsilaklppkgklrslcsqhverlqifqhlhpivvqaafp
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ntqA (A:)
    aslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhl
    teaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkygg
    melfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqy
    nlelafhhhlskthrqsilaklppkgklrslcsqhverlqifqhlhpivvqaaf
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5ntqB (B:)
    gpyaslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwerca
    hhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegk
    yggmelfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveq
    lqynlelafhhhlskthrqsilaklppkgklrslcsqhverlqifqhlhpivvqaafp
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ntqB (B:)
    aslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhl
    teaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkygg
    melfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqy
    nlelafhhhlskthrqsilaklppkgklrslcsqhverlqifq