PDB entry 5nhz

View 5nhz on RCSB PDB site
Description: VIM-2_10b. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding
Class: hydrolase
Keywords: inhibition properties, bioisosters, thiols, metallo-beta-lactamase inhibitor, hydrolase
Deposited on 2017-03-22, released 2017-04-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-lactamase class b vim-2
    Species: Pseudomonas aeruginosa [TaxId:287]
    Gene: blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nhza_
  • Chain 'B':
    Compound: beta-lactamase class b vim-2
    Species: Pseudomonas aeruginosa [TaxId:287]
    Gene: blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nhzb_
  • Heterogens: ZN, 8XZ, CL, PO4, SO4, PEG, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nhzA (A:)
mfkllskllvyltasimaiasplafsvdssgeyptvseipvgevrlyqiadgvwshiatq
sfdgavypsnglivrdgdelllidtawgakntaallaeiekqiglpvtravsthfhddrv
ggvdvlraagvatyaspstrrlaevegneipthsleglsssgdavrfgpvelfypgaahs
tdnlvvyvpsasvlyggcaiyelsrtsagnvadadlaewptsieriqqhypeaqfvipgh
glpggldllkhttnvvkahtnrsvve

    Sequence, based on observed residues (ATOM records): (download) 
    >5nhzA (A:)
eyptvseipvgevrlyqiadgvwshiatqsfdgavypsnglivrdgdelllidtawgakn
taallaeiekqiglpvtravsthfhddrvggvdvlraagvatyaspstrrlaevegneip
thsleglsssgdavrfgpvelfypgaahstdnlvvyvpsasvlyggcaiyelsrtsagnv
adadlaewptsieriqqhypeaqfvipghglpggldllkhttnvvkahtn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nhzB (B:)
mfkllskllvyltasimaiasplafsvdssgeyptvseipvgevrlyqiadgvwshiatq
sfdgavypsnglivrdgdelllidtawgakntaallaeiekqiglpvtravsthfhddrv
ggvdvlraagvatyaspstrrlaevegneipthsleglsssgdavrfgpvelfypgaahs
tdnlvvyvpsasvlyggcaiyelsrtsagnvadadlaewptsieriqqhypeaqfvipgh
glpggldllkhttnvvkahtnrsvve

    Sequence, based on observed residues (ATOM records): (download) 
    >5nhzB (B:)
eyptvseipvgevrlyqiadgvwshiatqsfdgavypsnglivrdgdelllidtawgakn
taallaeiekqiglpvtravsthfhddrvggvdvlraagvatyaspstrrlaevegneip
thsleglsssgdavrfgpvelfypgaahstdnlvvyvpsasvlyggcaiyelsrtsagnv
adadlaewptsieriqqhypeaqfvipghglpggldllkhttnvvkahtn