PDB entry 5n9r

View 5n9r on RCSB PDB site
Description: Crystal structure of USP7 in complex with a potent, selective and reversible small-molecule inhibitor
Class: hydrolase
Keywords: USP7, reversible, inhibitor, selective, HYDROLASE
Deposited on 2017-02-27, released 2017-12-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93009 (1-354)
      • initiating methionine (0)
      • expression tag (355-356)
    Domains in SCOPe 2.06: d5n9ra1, d5n9ra2
  • Chain 'B':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93009 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d5n9rb_
  • Heterogens: SO4, GOL, 8RN, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5n9rA (A:)
mskkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfy
elqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfr
gkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehg
lqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdp
anyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddl
svrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqkrkerqehh

    Sequence, based on observed residues (ATOM records): (download) 
    >5n9rA (A:)
mskkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfy
elqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfr
gkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehg
lqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdp
anyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghddls
vrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqkrkerqehh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5n9rB (B:)
mskkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfy
elqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfr
gkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehg
lqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdp
anyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddl
svrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqkrkerqehh

    Sequence, based on observed residues (ATOM records): (download) 
    >5n9rB (B:)
mskkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfy
elqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfr
gkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehg
lqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdp
anyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddl
svrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekriea