PDB entry 5n4s

View 5n4s on RCSB PDB site
Description: VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan (Compound 3)
Class: hydrolase
Keywords: metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, HYDROLASE
Deposited on 2017-02-11, released 2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.64 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-lactamase vim-2
    Species: Pseudomonas aeruginosa [TaxId:287]
    Gene: blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9K2N0 (1-230)
      • expression tag (0)
      • expression tag (231)
    Domains in SCOPe 2.08: d5n4sa1, d5n4sa2, d5n4sa3
  • Chain 'B':
    Compound: beta-lactamase vim-2
    Species: Pseudomonas aeruginosa [TaxId:287]
    Gene: blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9K2N0 (1-230)
      • expression tag (0)
    Domains in SCOPe 2.08: d5n4sb1, d5n4sb2
  • Heterogens: ZN, R38, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5n4sA (A:)
ayptvseipvgevrlyqiadgvwshiatqsfdgavypsnglivrdgdelllidtawgakn
taallaeiekqiglpvtravsthfhddrvggvdvlraagvatyaspstrrlaevegneip
thsleglsssgdavrfgpvelfypgaahstdnlvvyvpsasvlyggcaiyelsrtsagnv
adadlaewptsieriqqhypeaqfvipghglpggldllkhttnvvkahtnra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5n4sB (B:)
ayptvseipvgevrlyqiadgvwshiatqsfdgavypsnglivrdgdelllidtawgakn
taallaeiekqiglpvtravsthfhddrvggvdvlraagvatyaspstrrlaevegneip
thsleglsssgdavrfgpvelfypgaahstdnlvvyvpsasvlyggcaiyelsrtsagnv
adadlaewptsieriqqhypeaqfvipghglpggldllkhttnvvkahtnra

    Sequence, based on observed residues (ATOM records): (download) 
    >5n4sB (B:)
ayptvseipvgevrlyqiadgvwshiatqsfdgavypsnglivrdgdelllidtawgakn
taallaeiekqiglpvtravsthfhddrvggvdvlraagvatyaspstrrlaevegneip
thsleglsssgdavrfgpvelfypgaahstdnlvvyvpsasvlyggcaiyelsrtsagnv
adadlaewptsieriqqhypeaqfvipghglpggldllkhttnvvkahtnr