PDB entry 5n1b

View 5n1b on RCSB PDB site
Description: hPAD4 crystal complex with AFM-14a
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-02-06, released 2017-05-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-29, with a file datestamp of 2017-11-24.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein-arginine deiminase type-4
    Species: Homo sapiens [TaxId:9606]
    Gene: PADI4, PAD4, PADI5, PDI5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM07 (Start-669)
      • engineered mutation (88)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d5n1ba1, d5n1ba2, d5n1ba3
  • Heterogens: SO4, CA, 8FW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5n1bA (A:)
gplgspqmaqgtlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdia
hsppakkkstgsstwpldpgvevtltmkaasgstgdqkvqisyygpktppvkallyltav
eislcaditrtgkvkptravkdqrtwtwgpcgqgaillvncdrdnlessamdceddevld
sedlqdmslmtlstktpkdfftnhtlvlhvarsemdkvrvfqatrgklsskcsvvlgpkw
pshylmvpggkhnmdfyvealafpdtdfpglitltislldtsnlelpeavvfqdsvvfrv
apwimtpntqppqevyacsifenedflksvttlamkakcklticpeeenmddqwmqdeme
igyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlevs
ppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghvd
eflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsnk
tlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvlg
khlgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhcgtnvrrkp
fsfkwwnmvp

    Sequence, based on observed residues (ATOM records): (download) 
    >5n1bA (A:)
tlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdistwpldpgvevt
ltmkaasgstgdqkvqisyygpktppvkallyltaveislcaditrtgrtwtwgpcgqga
illvncdrdnlessamdceddevldsedlqdmslmtlstktpkdfftnhtlvlhvarsem
dkvrvfqacsvvlgpkwpshylmvpggkhnmdfyvealafpdtdfpglitltislldtsn
lelpeavvfqdsvvfrvapwimtpntqppqevyacsifenedflksvttlamkakcklti
cpeeenmddqwmqdemeigyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgp
qtggisgldsfgnlevsppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqv
qapvklysdwlsvghvdeflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfe
gikkkkqqkiknilsnktlrehnsfvercidwnrellkrelglaesdiidipqlfklkef
skaeaffpnmvnmlvlgkhlgipkpfgpvingrccleekvcslleplglqctfindffty
hirhgevhcgtnvrrkpfsfkwwnmvp