PDB entry 5m70

View 5m70 on RCSB PDB site
Description: Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human
Class: signaling protein
Keywords: RHOGAP, Arginine finger, RHOA, transition state, signaling protein
Deposited on 2016-10-26, released 2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho GTPase-activating protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGAP1, CDC42GAP, RHOGAP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07960
      • conflict (84)
    Domains in SCOPe 2.08: d5m70a_
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586
      • conflict (23)
    Domains in SCOPe 2.08: d5m70b_
  • Chain 'F':
    Compound: Rho GTPase-activating protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGAP1, CDC42GAP, RHOGAP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07960
      • conflict (84)
    Domains in SCOPe 2.08: d5m70f_
  • Chain 'G':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586
      • conflict (23)
    Domains in SCOPe 2.08: d5m70g_
  • Heterogens: MG, GDP, ALF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5m70A (A:)
hvkleqlgiprqvlkyddflkstqkspatapkpmpprpplpnqqfgvslqhlqeknpeqe
pipivlretvaylqahalttegifarsantqvvrevqqkynmglpvdfdqynelhlpavi
lktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpeenyqvlrfltaflvq
isahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkflldhqgelfpspdps

    Sequence, based on observed residues (ATOM records): (download) 
    >5m70A (A:)
qqfgvslqhlqeknpipivlretvaylqahalttegifarsantqvvrevqqkynmglpv
dfdqynelhlpavilktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpee
nyqvlrfltaflvqisahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkfl
ldhqgelf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5m70B (B:)
aairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdta
gqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdl
rndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa
rrgkkksgclvl

    Sequence, based on observed residues (ATOM records): (download) 
    >5m70B (B:)
rkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievqvelalwdtagqedyd
rlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndeht
rrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraal

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5m70F (F:)
hvkleqlgiprqvlkyddflkstqkspatapkpmpprpplpnqqfgvslqhlqeknpeqe
pipivlretvaylqahalttegifarsantqvvrevqqkynmglpvdfdqynelhlpavi
lktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpeenyqvlrfltaflvq
isahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkflldhqgelfpspdps

    Sequence, based on observed residues (ATOM records): (download) 
    >5m70F (F:)
qqfgvslqhlqeknpipivlretvaylqahalttegifarsantqvvrevqqkynmglpv
dfdqynelhlpavilktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpee
nyqvlrfltaflvqisahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkfl
ldhqgelf

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5m70G (G:)
aairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdta
gqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdl
rndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa
rrgkkksgclvl

    Sequence, based on observed residues (ATOM records): (download) 
    >5m70G (G:)
rkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievqvelalwdtagqedyd
rlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndeht
rrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraal