PDB entry 5m6x
View 5m6x on RCSB PDB site
Description: Crystal Structure of human RhoGAP mutated in its arginine finger (R85A) in complex with RhoA.GDP.MgF3- human
Class: signaling protein
Keywords: RHOGAP, Arginine finger, RHOA, transition state, Signaling protein
Deposited on
2016-10-26, released
2017-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-09-06, with a file datestamp of
2017-09-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Rho GTPase-activating protein 1
Species: Homo sapiens [TaxId:9606]
Gene: ARHGAP1, CDC42GAP, RHOGAP1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5m6xa_ - Chain 'B':
Compound: transforming protein rhoa
Species: Homo sapiens [TaxId:9606]
Gene: RHOA, ARH12, ARHA, RHO12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5m6xb_ - Chain 'H':
Compound: Rho GTPase-activating protein 1
Species: Homo sapiens [TaxId:9606]
Gene: ARHGAP1, CDC42GAP, RHOGAP1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5m6xh_ - Chain 'I':
Compound: transforming protein rhoa
Species: Homo sapiens [TaxId:9606]
Gene: RHOA, ARH12, ARHA, RHO12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5m6xi_ - Heterogens: MG, GDP, MGF, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5m6xA (A:)
hvkleqlgiprqvlkyddflkstqkspatapkpmpprpplpnqqfgvslqhlqeknpeqe
pipivlretvaylqahalttegifarsantqvvrevqqkynmglpvdfdqynelhlpavi
lktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpeenyqvlrfltaflvq
isahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkflldhqgelfpspdps
Sequence, based on observed residues (ATOM records): (download)
>5m6xA (A:)
qqfgvslqhlqeknpipivlretvaylqahalttegifarsantqvvrevqqkynmglpv
dfdqynelhlpavilktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpee
nyqvlrfltaflvqisahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkfl
ldhqgelf
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5m6xB (B:)
aairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdta
gqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdl
rndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa
rrgkkksgclvl
Sequence, based on observed residues (ATOM records): (download)
>5m6xB (B:)
airkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
- Chain 'H':
Sequence, based on SEQRES records: (download)
>5m6xH (H:)
hvkleqlgiprqvlkyddflkstqkspatapkpmpprpplpnqqfgvslqhlqeknpeqe
pipivlretvaylqahalttegifarsantqvvrevqqkynmglpvdfdqynelhlpavi
lktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpeenyqvlrfltaflvq
isahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkflldhqgelfpspdps
Sequence, based on observed residues (ATOM records): (download)
>5m6xH (H:)
qqfgvslqhlqekpipivlretvaylqahalttegifarsantqvvrevqqkynmglpvd
fdqynelhlpavilktflrelpeplltfdlyphvvgflnidesqrvpatlqvlqtlpeen
yqvlrfltaflvqisahsdqnkmtntnlavvfgpnllwakdaaitlkainpintftkfll
dhqgelf
- Chain 'I':
Sequence, based on SEQRES records: (download)
>5m6xI (I:)
aairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdta
gqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdl
rndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa
rrgkkksgclvl
Sequence, based on observed residues (ATOM records): (download)
>5m6xI (I:)
irkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtagq
edydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrn
dehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa