PDB entry 5m4z

View 5m4z on RCSB PDB site
Description: Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate
Class: transferase
Keywords: enzyme-inhibitor complex, high-resolution structure, anticancer target, transferase
Deposited on 2016-10-19, released 2017-12-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 1.18 Å
R-factor: N/A
AEROSPACI score: 0.67 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Trichinella spiralis [TaxId:6334]
    Gene: ts, Tsp_03568
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5m4za_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Trichinella spiralis [TaxId:6334]
    Gene: ts, Tsp_03568
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5m4zb_
  • Heterogens: 7K8, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5m4zA (A:)
mkhhhhhhhmhaqmtetvhkldtnstsqddyvnqeelnylnqlkdiidhgvrkndrtgig
tlstfgtqsryclrddifpllttkrvfwrgvveellwfisgstnakqlseknvniwdgns
srefldsrglynyeegdlgpvygfqwrhfgcpyssmtadykgkgydqlqqcikmireepe
srriimtawnpcdlekvalppchcfvqfyvadgelscqmyqrsadmglgvpfniasysll
trmiahitslkpgffihtigdahvylthvdalkvqmerkprpfpklkilrnveniddfra
edfelinykpypkismpmav

    Sequence, based on observed residues (ATOM records): (download) 
    >5m4zA (A:)
yvnqeelnylnqlkdiidhgvrkngigtlstfgtqsryclrddifpllttkrvfwrgvve
ellwfisgstnakqlseknvniwdgnssrefldsrglynyeegdlgpvygfqwrhfgcpy
ssmtadykgkgydqlqqcikmireepesrriimtawnpcdlekvalppchcfvqfyvadg
elscqmyqrsadmglgvpfniasyslltrmiahitslkpgffihtigdahvylthvdalk
vqmerkprpfpklkilrnveniddfraedfelinykpypkismpmav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5m4zB (B:)
mkhhhhhhhmhaqmtetvhkldtnstsqddyvnqeelnylnqlkdiidhgvrkndrtgig
tlstfgtqsryclrddifpllttkrvfwrgvveellwfisgstnakqlseknvniwdgns
srefldsrglynyeegdlgpvygfqwrhfgcpyssmtadykgkgydqlqqcikmireepe
srriimtawnpcdlekvalppchcfvqfyvadgelscqmyqrsadmglgvpfniasysll
trmiahitslkpgffihtigdahvylthvdalkvqmerkprpfpklkilrnveniddfra
edfelinykpypkismpmav

    Sequence, based on observed residues (ATOM records): (download) 
    >5m4zB (B:)
yvnqeelnylnqlkdiidhgvrkndrtgigtlstfgtqsryclrddifpllttkrvfwrg
vveellwfisgstnakqlseknvniwdgnssrefldsrglynyeegdlgpvygfqwrhfg
cpyssmtadykgkgydqlqqcikmireepesrriimtawnpcdlekvalppchcfvqfyv
adgelscqmyqrsadmglgvpfniasyslltrmiahitslkpgffihtigdahvylthvd
alkvqmerkprpfpklkilrnveniddfraedfelinykpypkism