SCOPe 2.06: Structural Classification of Proteins

PDB entry 5m2m

View 5m2m on RCSB PDB site
Description: Complex between human TNF alpha and Llama VHH3
Class: cytokine
Keywords: human TNF alpha, Llama nanobody, cytokine
Deposited on 2016-10-13, released 2017-08-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2ma_
Chain 'B':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2mb_
Chain 'C':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2mc_
Chain 'D':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2md_
Chain 'E':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2me_
Chain 'F':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2mf_
Chain 'G':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2mg_
Chain 'H':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2mh_
Chain 'I':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2mi_
Chain 'J':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2mj_
Chain 'M':
Compound: Tumor necrosis factor
Species: Homo sapiens [TaxId:9606]
Gene: TNF, TNFA, TNFSF2
Database cross-references and differences (RAF-indexed):
- Uniprot P01375 (Start-156)
Domains in SCOPe 2.06: d5m2mm_
Chain 'N':
Compound: Llama nanobody VHH3
Species: Lama glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- PDB 5M2M (Start-128)
Domains in SCOPe 2.06: d5m2mn_
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>5m2mA (A:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial