PDB entry 5lr6
View 5lr6 on RCSB PDB site
Description: Crystal Structure of COMT in complex with [3-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-5-yl]-(4-phenylpiperazin-1-yl)methanone
Class: transferase
Keywords: methyltransferase, neurotransmitter degradation, transferase
Deposited on
2016-08-18, released
2016-08-31
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-08-31, with a file datestamp of
2016-08-24.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- conflict (90)
- conflict (94)
Domains in SCOPe 2.06: d5lr6a_ - Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- conflict (90)
- conflict (94)
Domains in SCOPe 2.06: d5lr6b_ - Chain 'C':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- conflict (90)
- conflict (94)
Domains in SCOPe 2.06: d5lr6c_ - Chain 'D':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
- conflict (90)
- conflict (94)
Domains in SCOPe 2.06: d5lr6d_ - Heterogens: 731, NHE, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5lr6A (A:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5lr6A (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamvgdakgqimdavireyspslv
lelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdl
ipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflay
vrgsssfecthyssylmkvvdglekaiyqgps
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5lr6B (B:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5lr6B (B:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewvgdakgqimdavireyspslvle
lgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdlip
qlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflayvr
gsssfecthyssyleymkvvdglekaiyqgps
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5lr6C (C:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5lr6C (C:)
dtkeqrilryvqqnakpgdpqsvleaidtyctqkewanvgdakgqimdavireyspslvl
elgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdli
pqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflayv
rgsssfecthyssyleymkvvdglekaiyqgpss
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5lr6D (D:)
mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
Sequence, based on observed residues (ATOM records): (download)
>5lr6D (D:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgp