PDB entry 5lhp
View 5lhp on RCSB PDB site
Description: The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Class: hydrolase
Keywords: Trypsin-like serine proteases, Nanobody, Inhibitor, hydrolase
Deposited on
2016-07-12, released
2017-06-28
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-06-28, with a file datestamp of
2017-06-23.
Experiment type: XRAY
Resolution: 2.63 Å
R-factor: N/A
AEROSPACI score: 0.19
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: urokinase-type plasminogen activator
Species: Mus musculus [TaxId:10090]
Gene: PLAU
Database cross-references and differences (RAF-indexed):
- Uniprot P06869 (0-246)
- engineered mutation (121)
Domains in SCOPe 2.07: d5lhpa_ - Chain 'B':
Compound: Camelid-Derived Antibody Fragment
Species: Vicugna pacos [TaxId:30538]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d5lhpb1, d5lhpb2 - Heterogens: SO4, EDO, PBZ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>5lhpA (A:)
ivggeftevenqpwfaaiyqknkggsppsfkcggslispcwvasaahcfiqlpkkenyvv
ylgqskessynpgemkfeveqlilheyyredslayhndiallkirtstgqcaqpsrsiqt
ialpprftdapfgsdceitgfgkesesdylypknlkmsvvklvsheqcmqphyygseiny
kmlcaadpewktdsckgdsggplicniegrptlsgivswgrgcaeknkpgvytrvshfld
wiqshig
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5lhpB (B:)
qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
eywgkgtqvtvssaaaypydvpdygshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>5lhpB (B:)
qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
eywgkgtqvtvssaa