PDB entry 5lhp

View 5lhp on RCSB PDB site
Description: The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Class: hydrolase
Keywords: Trypsin-like serine proteases, Nanobody, Inhibitor, hydrolase
Deposited on 2016-07-12, released 2017-06-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 2.63 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: urokinase-type plasminogen activator
    Species: Mus musculus [TaxId:10090]
    Gene: PLAU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06869 (0-246)
      • engineered mutation (121)
    Domains in SCOPe 2.07: d5lhpa_
  • Chain 'B':
    Compound: Camelid-Derived Antibody Fragment
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5LHP (0-End)
    Domains in SCOPe 2.07: d5lhpb1, d5lhpb2
  • Heterogens: SO4, EDO, PBZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5lhpA (A:)
    ivggeftevenqpwfaaiyqknkggsppsfkcggslispcwvasaahcfiqlpkkenyvv
    ylgqskessynpgemkfeveqlilheyyredslayhndiallkirtstgqcaqpsrsiqt
    ialpprftdapfgsdceitgfgkesesdylypknlkmsvvklvsheqcmqphyygseiny
    kmlcaadpewktdsckgdsggplicniegrptlsgivswgrgcaeknkpgvytrvshfld
    wiqshig
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5lhpB (B:)
    qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
    adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
    eywgkgtqvtvssaaaypydvpdygshhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5lhpB (B:)
    qvqlqesggglvqpggslrlscaasgftlgyyaigwfrrapgkeregvscisssggstny
    adsvkgrftisrdnakntvdlqmnslkpedtaiyycaaewvppgygatvqalcnnagygm
    eywgkgtqvtvssaa