PDB entry 5l30
View 5l30 on RCSB PDB site
Description: Factor VIIa in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, Hydrolase-Hydrolase Inhibitor complex
Deposited on
2016-08-02, released
2016-09-28
The last revision prior to the SCOPe 2.07 freeze date was dated
2016-10-12, with a file datestamp of
2016-10-07.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Coagulation factor VII (heavy chain)
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d5l30h_ - Chain 'L':
Compound: Coagulation factor VII (light chain)
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d5l30l_ - Heterogens: 70A, CA, SO4, GOL, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>5l30H (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
Sequence, based on observed residues (ATOM records): (download)
>5l30H (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrdspniteymfcagysdg
skdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsep
rpgvllrapfp
- Chain 'L':
Sequence, based on SEQRES records: (download)
>5l30L (L:)
dqlicvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr
Sequence, based on observed residues (ATOM records): (download)
>5l30L (L:)
licvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr