PDB entry 5l2y

View 5l2y on RCSB PDB site
Description: Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2016-08-02, released 2016-09-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-10-12, with a file datestamp of 2016-10-07.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'H':
  Compound: Coagulation factor VII (heavy chain)
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-253)
  Domains in SCOPe 2.07: d5l2yh_
• Chain 'L':
  Compound: Coagulation factor VII (light chain)
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-54)
  Domains in SCOPe 2.07: d5l2yl_
• Heterogens: 70D, CA, SO4, GOL, HOH

PDB Chain Sequences:

• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5l2yH (H:)
  ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
  lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
  lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
  sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
  seprpgvllrapfp
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >5l2yL (L:)
  icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr