PDB entry 5l21

View 5l21 on RCSB PDB site
Description: Crystal structure of BoNT/A receptor binding domain in complex with VHH C2
Class: toxin
Keywords: Neutralizing antibody; VHH; Botulinum neurotoxin; BoNT-A-VHH complex, TOXIN
Deposited on 2016-07-29, released 2017-08-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Botulinum neurotoxin type A
    Species: Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) [TaxId:441771]
    Gene: botA, CBO0806, CLC_0862
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5HZZ9 (3-427)
      • cloning artifact (0-2)
      • engineered mutation (289)
    Domains in SCOPe 2.08: d5l21a1, d5l21a2, d5l21a3
  • Chain 'B':
    Compound: vhh-c2
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5L21 (0-118)
    Domains in SCOPe 2.08: d5l21b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5l21A (A:)
gpmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievil
knaivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlq
dtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnih
asnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqyd
kpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkyasg
nkdnivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmksknd
qgitnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvd
dgwgerpl

    Sequence, based on observed residues (ATOM records): (download) 
    >5l21A (A:)
gpmniintsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievil
knaivynsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlq
dtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnih
asnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqyd
kpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgakfiikkynkd
nivrnndrvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmkskndqgi
tnkckmnlqdnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvddgw
gerpl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5l21B (B:)
qvqlvesggglaqpggslrlsceasgfgtwfrfdentvnwyrqppgksrefdelvarypk
sgivtyldsvkgrftisrdnakkmaflqmdnlkpedtavyycnvgefwgqgtqvtisse