PDB entry 5kyk
View 5kyk on RCSB PDB site
Description: Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: KRAS, Cancer, covalent inhibitor, HYDROLASE-HYDROLASE inhibitor complex
Deposited on
2016-07-21, released
2017-04-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-04-12, with a file datestamp of
2017-04-07.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d5kyka1, d5kyka2 - Chain 'B':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-168)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d5kykb1, d5kykb2 - Chain 'C':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-168)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d5kykc1, d5kykc2 - Heterogens: 6ZD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5kykA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
Sequence, based on observed residues (ATOM records): (download)
>5kykA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtagqer
dqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtk
qaqdlarsygipfietsaktrqgvddafytlvreirkhk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5kykB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
Sequence, based on observed residues (ATOM records): (download)
>5kykB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeyddsyrkqvvidgetclldildtagqer
dqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtk
qaqdlarsygipfietsaktrqgvddafytlvreirkhke
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5kykC (C:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
Sequence, based on observed residues (ATOM records): (download)
>5kykC (C:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydpdsyrkqvvidgetclldildtagqe
samrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrt
vdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke