PDB entry 5kyc

View 5kyc on RCSB PDB site
Description: Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound)
Class: hydrolase
Keywords: USP7 catalytic domain, deubiquitinase, V302K mutation, HYDROLASE
Deposited on 2016-07-21, released 2017-08-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-08-09, with a file datestamp of 2017-08-04.
Experiment type: XRAY
Resolution: 1.43 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Ubiquitin carboxyl-terminal hydrolase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: USP7, HAUSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93009
      • engineered mutation (98)
    Domains in SCOPe 2.06: d5kycb_
  • Chain 'C':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5kycc_
  • Heterogens: MLA, GOL, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5kycB (B:)
    gshmkkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrv
    fyelqhsdkpvgtkkltksfgwetldsfmqhdvqelcrklldnvenkmkgtcvegtipkl
    frgkmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydage
    hglqeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpk
    dpanyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdd
    dlsvrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqk
    

    Sequence, based on observed residues (ATOM records): (download)
    >5kycB (B:)
    htgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfyelqh
    sdkpvgtkkltksfgwetldsfmqhdvqelcrklldnvenkmkgtcvegtipklfrgkmv
    syiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehglqea
    ekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpanyi
    lhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddlsvrh
    ctnaymlvyiresklsevlqavtdhdipqqlverlqeekr
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5kycC (C:)
    mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
    iqkestlhlvlrlrgg