PDB entry 5ke0

View 5ke0 on RCSB PDB site
Description: Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers
Class: transferase/transferase inhibitor
Keywords: transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex
Deposited on 2016-06-09, released 2016-07-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Mapk1, Erk2, Mapk, Prkm1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ke0a_
  • Heterogens: 6S9, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ke0A (A:)
mahhhhhhmaaaaaagpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaik
kispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlyk
llktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarva
dpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyl
dqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkml
tfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarf
qpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >5ke0A (A:)
vfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreikillr
frheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrgl
kyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciin
lkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyy
dpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg